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UID:0-8019@eng.ufl.edu
DTSTART;TZID=America/New_York:20260309T150000
DTEND;TZID=America/New_York:20260309T160000
DTSTAMP:20260105T130905Z
URL:https://www.eng.ufl.edu/news-events/events/bme-seminar-mechano-metabol
 ic-crosstalk-in-cardiovascular-disease/
SUMMARY:BME Seminar: “Mechano-Metabolic Crosstalk in Cardiovascular Disea
 se"
DESCRIPTION:Alisa Morss Clyne\, Ph.D.\nKeystone Professor\, Fischell Depart
 ment of Bioengineering\nUniversity of Maryland\nAbstract: Cardiovascular d
 isease progresses due to disordered mechanics and metabolism. In a healthy
  blood vessel\, endothelial cells respond to mechanical signals from the f
 lowing blood at their apical surface and the parenchymal tissue at their b
 asolateral surface. At the same time\, endothelial cells take up metabolit
 es from the blood\, use some of these metabolites for their own function\,
  transport the remaining metabolites into the parenchymal tissue\, and the
 n secrete metabolic byproducts into the blood or tissue. However\, in card
 iovascular disease the mechanical signals may be altered by disturbed bloo
 d flow or by stiffened arteries\, and the availability of specific metabol
 ites (e.g.\, glucose\, fatty acids) may be abnormally high. In this talk\,
  I will describe how we use a combination of in vitro\, ex vivo\, and comp
 utational models to understand the connections between endothelial cell me
 chanics and metabolism.\nBio: Alisa Morss Clyne is currently a Keystone Pr
 ofessor in the Fischell Department of Bioengineering at the University of 
 Maryland. Prior to joining the University of Maryland in January 2019\, sh
 e was in the Mechanical Engineering department at Drexel University in Phi
 ladelphia\, PA for 12 years. Dr. Clyne directs the Vascular Kinetics Labor
 atory\, which investigates integrated mechanical and biochemical interacti
 ons among cells and proteins of the cardiovascular system. She is particul
 arly interested in how using advanced in vitro and computational models to
  understand how fluid shear stress and substrate mechanics affect nutrient
  metabolism and transport. Dr. Clyne received her bachelor’s degree in M
 echanical Engineering from Stanford University in 1996. She worked as an e
 ngineer in the GE Aircraft Engines Technical Leadership Program for four y
 ears\, concurrently earning her master’s degree in Mechanical Engineerin
 g from the University of Cincinnati. In 2006\, she received her Doctorate 
 in Medical and Mechanical Engineering from the Harvard-MIT Division of Hea
 lth Sciences and Technology. Dr. Clyne is a fellow of the American Society
  of Mechanical Engineers (ASME)\, the American Heart Association (AHA)\, t
 he American Institute for Medical and Biological Engineering (AIMBE)\, and
  the Biomedical Engineering Society (BMES). She received the NSF CAREER aw
 ard in 2008\, an AHA National Scientist Development Grant in 2010\, the BM
 ES-CMBE Rising Star award in 2011\, the AWIS Elizabeth Bingham Mentoring a
 ward in 2017\, and the ASME Van C. Mow Medal in 2026. Her research\, teach
 ing\, and mentoring has been funded by NSF\, NIH\, and the AHA among other
 s\, and she has published more than 70 peer-reviewed publications in leadi
 ng journals. Her teaching focuses on engineering applications in biologica
 l systems\, and she founded several programs to enhance engineering opport
 unities for all.
CATEGORIES:Seminars
LOCATION:Communicore Room C1-4\, 1249 Center Dr.\, Gainesville\, Florida\, 
 32610\, United States
GEO:29.648381;-82.348511
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 le\, Florida\, 32610\, United States;X-APPLE-RADIUS=100;X-TITLE=Communicor
 e Room C1-4:geo:29.648381,-82.348511
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DTSTART:20260308T030000
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