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UID:0-5561@eng.ufl.edu
DTSTART;TZID=America/New_York:20230221T091500
DTEND;TZID=America/New_York:20230221T101500
DTSTAMP:20251201T182456Z
URL:https://www.eng.ufl.edu/news-events/events/che-seminar-expanding-the-f
 unctionality-of-engineered-extracellular-matrices-with-peptoids/
SUMMARY:ChE Seminar: Expanding the Functionality of Engineered Extracellula
 r Matrices with Peptoids
DESCRIPTION:Adrianne M. Rosales\, Ph.D.\nAssistant Professor\nMcKetta Depar
 tment of Chemical Engineering\nThe University of Texas at Austin\n\nTitle:
  Expanding the Functionality of Engineered Extracellular Matrices with Pep
 toids\n\nAbstract: Hydrogels have garnered intense interest as engineered 
 extracellular matrices due to their tailorable permeability\, mechanics\, 
 and degradability. Synthetic materials are attractive due to their known c
 hemical compositions and reproducibility\, but the challenge with their us
 e lies in the lack of complexity as compared to biological systems\, espec
 ially with regard to sequence-specific bioactivity. Hence\, our work aims 
 to expand the toolbox for building complexity and functionality into synth
 etic hydrogel biomaterials by using precise polymer architectures\, specif
 ically those of peptoids. Here\, we describe our efforts to control two ke
 y properties of hydrogels with peptoid functionality: 1) bulk mechanics an
 d 2) enzymatic degradability. Using peptoid crosslinkers\, we achieved con
 trol over the mechanics of hydrogel platforms by varying monomer sequence 
 and chain structure\, in a fashion reminiscent of semiflexible biopolymers
 . Specifically\, helical peptoids increased the shear moduli of hydrogels 
 due to increased chain stiffness as compared to non-helical peptoids\, whi
 le keeping all other hydrogel parameters fixed. These changes in mechanics
  impacted the amount of secreted stem cell factors such as indoleamine 2\,
 3-dioxygenase (IDO)\, leading to conditions that promoted more therapeutic
 ally relevant cells. Furthermore\, we examined the ability of peptoids to 
 tune hydrogel degradability via proteolysis. We substituted peptoids into 
 key sites of proteolytically degradable substrates\, enabling a tailored m
 aterial response to matrix metalloproteinases secreted by cells. Overall\,
  our results suggest that sequence control of synthetic peptoids may provi
 de effective strategies for expanding the functionality of biomaterial sca
 ffolds for tissue engineering\, particularly with respect to mechanics and
  degradation in complex biological environments.\n\nBio: Adrianne Rosales
  is an Assistant Professor of Chemical Engineering at the University of Te
 xas at Austin. She received her B.S. in Chemical Engineering from UT Austi
 n and obtained her Ph.D. in Chemical Engineering from UC-Berkeley. After c
 ompleting her Ph.D. in 2013\, she trained at the University of Colorado Bo
 ulder as an NIH NRSA post-doctoral fellow. Adrianne's group at UT Austin 
 focuses on the development of bioinspired polymeric materials to model cel
 lular microenvironments and engineer therapeutic technologies. This work
  has received emerging investigator recognitions from the Burroughs Wellc
 ome Fund\, the NIH\, the NSF\, the American Chemical Society Polymeric Mat
 erials: Science and Engineering Division\, and the journals Biomaterials 
 Science and Journal of Materials Chemistry B.
CATEGORIES:Seminars
LOCATION:Room 201\, Engineering Building (NEB)\,  1064 Center Drive\, Gaine
 sville \, FL\, 32611\, United States
X-APPLE-STRUCTURED-LOCATION;VALUE=URI;X-ADDRESS= 1064 Center Drive\, Gaines
 ville \, FL\, 32611\, United States;X-APPLE-RADIUS=100;X-TITLE=Room 201\, 
 Engineering Building (NEB):geo:0,0
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DTSTART:20221106T010000
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