1064 CENTER DR
Gainesville, FL 32611
Bio-inspired Engineering: DNA-encoded Nanomechanical Systems
School of Mechanical engineering
Living organisms are best engineers. They build systems with complex morphologies and diverse functions in a highly efficient manner. DNA, which stores genetic information, templates material synthesis and regulates organism behaviors, gives rise to biological systems’ superb engineering capabilities. The technological advancements in reading and writing DNA sequences translate it into a programmable material suitable for engineering applications. My talk will demonstrate how the information encoding capability of DNA can be harnessed to program mechanical and transport properties at the nanoscale. In the first part, I will focus on DNA programmed nanomachinery. These nanomachines have diverse molecular functions such as sensing, computation and actuation. In particular, I will demonstrate a DNA based synthetic molecular motor that actively transports nanoparticles, mimicking biological motor proteins. The system’s kinetics, scaling features, regulation mechanisms and design principles will be discussed. In the second part, I will discuss DNA programmed self-assembly of nanostructures (DNA origami). I will demonstrate the mechanical properties of DNA can be used to dynamically control nanostructure confirmation. The talk will also include exemplary applications in biomedical diagnostics and therapeutics.
Jing Pan is a postdoctoral researcher in Mechanical Engineering at Purdue University. He received his B.S. in Mechanical Engineering from Xi’an Jiaotong University in China, and earned his doctoral degree in 2017 from Purdue University. He conducted his Ph.D. and postdoctoral research with Prof. Jong Hyun Choi at Purdue. He served as the head TA at the Purdue ME Heat Transfer area in 2014~2017. He is the recipient of Purdue COE Outstanding Graduate Research Award and the Chinese Government Award for Outstanding Students Abroad. His research focuses on engineering nucleic acid encoded nanoscale functions and exploring their emerging applications in healthcare and material synthesis.