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UID:0-8275@eng.ufl.edu
DTSTART;TZID=America/New_York:20260312T125000
DTEND;TZID=America/New_York:20260312T134000
DTSTAMP:20260225T220147Z
URL:https://www.eng.ufl.edu/news-events/events/mae-seminar-the-blood-brain
 -barrier-and-beyond-complex-in-vitro-models-for-transport-and-neurological
 -diseas/
SUMMARY:MAE Seminar: The blood-brain barrier and beyond: Complex in vitro m
 odels for transport and neurological diseas
DESCRIPTION:MAE Seminar: The blood-brain barrier and beyond: Complex in vit
 ro models for transport and neurological disease\nDate: March 12\, 2026 \n
 Time: 12:50 PM Location: MAE-A 303\n\nDr. Roger Kamm\nCecil and Ida Green 
 Distinguished Professor \nMassachusetts Institute of Technology\nDepartmen
 ts of Biological Engineering and Mechanical Engineering\n\nAbstract\nWith 
 an aging population\, neurodegenerative diseases are increasing at a rate 
 that far outpaces other major disorders. Recent advances in the pharmaceut
 ical industry have yielded new drugs that slow cognitive decline in patien
 ts with Alzheimer’s disease\, with many additional candidates in the dev
 elopment pipeline. This progress\, together with improved understanding of
  the factors that drive diverse neurodegenerative diseases\, has intensifi
 ed interest in both optimizing drug delivery to the brain and assessing th
 erapeutic impact on symptom alleviation and disease progression. Innovativ
 e in vitro platforms are therefore needed to screen emerging therapies and
  enhance delivery of biologics to the central nervous system. This present
 ation will highlight our human iPS cell–based models that recapitulate t
 he in vivo morphology and function of the neurovascular unit. We will disc
 uss applications of these models to elucidate and promote the clearance of
  toxic amyloid from the brain in neurodegenerative diseases\, with the goa
 l of building a holistic framework of transport pathways relevant to both 
 therapeutic agents and amyloid species.\n\nBiography\nKamm’s research fo
 cuses on problems at the interface of biology and mechanics\, formerly in 
 cell and molecular mechanics\, and now in engineered living systems.  Curr
 ent interests are in developing models of healthy and diseased organ funct
 ion using microfluidic technologies\, with a focus on vascularization\, ca
 ncer and neurological disease.  Kamm is a member of the National Academies
  of Medicine and Engineering. He is co-founder of AIM Biotech\, a manufact
 urer of microfluidic systems for 3D culture.\n\nFaculty Host: Dr. Xin Tang
CATEGORIES:Seminars
LOCATION:MAE-A Room 303\, 939 Sweetwater Drive\, Gainesville\, FL\, 32611\,
  United States
GEO:29.643814;-82.34865
X-APPLE-STRUCTURED-LOCATION;VALUE=URI;X-ADDRESS=939 Sweetwater Drive\, Gain
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  303:geo:29.643814,-82.34865
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