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UID:0-5381@eng.ufl.edu
DTSTART;TZID=America/New_York:20221006T135500
DTEND;TZID=America/New_York:20221006T145500
DTSTAMP:20220926T143409Z
URL:https://www.eng.ufl.edu/news-events/events/ne-seminar-applications-of-
 fdopa-pet-imaging-for-treatment-planning-and-response-assessment/
SUMMARY:NE Seminar: "Applications of FDOPA PET Imaging for Treatment Planni
 ng and Response Assessment"
DESCRIPTION:Deanna Pafundi\, Ph.D.\nAssociate Program Director\nMayo Clinic
  Physics Residency Program\nDr. Deanna Pafundi was born in St. Petersburg
 \, FL and grew up in Zephyrhills\, Florida. Spent undergraduate (Nuclear a
 nd Radiological Engineering\, Summa Cum Laude\, 2000-2004) and graduate sc
 hool (Nuclear and Radiological Engineering Sciences under a DOE Grant\, 20
 05-2009) days at the University of Florida. Graduate work was under Dr. We
 sley Bolch working on the image-based pediatric hybrid computational phant
 om models. Worked at the Crystal River Nuclear Power Plant in summer of 20
 03 during their fuel reload. Worked for the Transuranium and Uranium Regis
 tries in the Summer of 2006. Accepted into the 3 year residency program at
  Mayo Clinic in Rochester\, MN from 2009-2012. Joined the staff in 2012 af
 ter residency and stayed there until June 2019. Received the Mayo Fellows
 ’ Association Honor of Excellence in Teaching in 2019. Opportunity to mo
 ve back home to Florida and work at the Mayo Clinic in Florida. Started wo
 rking there in July 2019. I am the associate program director for the phys
 ics residency program and at Mayo Clinic Florida I am also very active in 
 AAPM. I have served on the Working Group for Imaging in Treatment Planning
  under the Therapy Physics Committee since 2015. 2016 vice chair\, and now
  chair since 2017. AAPM Task Group reviewer for 6 years. Also\, a member o
 f both the AAPM Working Group for Treatment Response Assessment and Therap
 y Imaging Subcommittee. I am currently being reviewed for academic promoti
 on into associate professor. I continue to research advanced imaging appli
 cations for radiotherapy applications\, especially with the upcoming proto
 n and carbon ion therapy center. I also maintain a heavy clinical practice
  with focus on AI applications in radiotherapy.\nAbstract\nPositron Emissi
 on Tomography (PET) image with amino-acid tracers such as 18F-DOPA has the
  ability to capture the cellular activities of gliomas with strong tumor-t
 o-normal tissue signal with superior sensitivity to tumoral infiltration a
 nd aggressiveness. The level of the Standardized Uptake Value (SUV) has be
 en utilized to define heterogeneity of the tumor and to guide radiation th
 erapy target delineation for improved outcomes. Furthermore\, complex sign
 als can be extracted from the distributions of the SUV histogram and textu
 re patterns to predict treatment response. These rich signals are highly d
 imensional and mineable but surrounded by a noisy system beyond the capabi
 lity of conventional quantitative analysis methods.\n\nRadiomics\, an emer
 ging field based on machine learning methods\, has become a powerful tool 
 for extracting quantitative signals from this noisy environment and studyi
 ng the correlation between various characteristics of the SUV distribution
 .\n\nThis presentation will take you through over a decade’s worth of da
 ta collected from several prospective trials at Mayo Clinic integrating FD
 OPA PET into radiotherapy treatment planning\, surgical resection/biopsy t
 argeting\, and treatment response predictions.
CATEGORIES:Seminars
LOCATION:Rhines Hall Room 125\, 549 Gale Lemerand Drive\, Gainesville\, FL\
 , 32611\, United States
GEO:29.644403;-82.350403
X-APPLE-STRUCTURED-LOCATION;VALUE=URI;X-ADDRESS=549 Gale Lemerand Drive\, G
 ainesville\, FL\, 32611\, United States;X-APPLE-RADIUS=100;X-TITLE=Rhines 
 Hall Room 125:geo:29.644403,-82.350403
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