{"id":22713,"date":"2017-12-20T11:31:02","date_gmt":"2017-12-20T16:31:02","guid":{"rendered":"https:\/\/www.eng.ufl.edu\/newengineer\/?p=22713"},"modified":"2025-06-11T12:32:55","modified_gmt":"2025-06-11T17:32:55","slug":"graphene-membrane-seeks-drastically-reduce-dialysis-time","status":"publish","type":"post","link":"https:\/\/www.eng.ufl.edu\/news\/mae\/graphene-membrane-seeks-drastically-reduce-dialysis-time\/","title":{"rendered":"Graphene Membrane Seeks to Drastically Reduce Dialysis Time"},"content":{"rendered":"
\"Saeed
Saeed Moghaddam is an associate professor in the UF Herbert Wertheim College of Engineering’s Department of Mechanical and Aerospace Engineering.<\/figcaption><\/figure>\n

You can\u2019t always buy time, but you just might be able to engineer some.<\/strong><\/p>\n

For those with renal failure, the process of kidney dialysis is all too familiar: Three times a week, for a cumulative 12 hours, you sit in a chair and a machine does what your bean-shaped organs can\u2019t\u2014in this case, filter toxins out of your blood.<\/p>\n

Although the treatment is an integral part of keeping those with advanced renal failure alive, patients\u2019 quality of life leaves something to be desired. Dialysis of any kind is an unavoidable time sink, and one whose filtration systems have seen little change over the years.<\/p>\n

But what if there was a way to make the process faster\u2014and cheaper?<\/p>\n

Saeed Moghaddam, Ph.D.<\/a>, an associate professor in UF\u2019s Department of Mechanical and Aerospace Engineering<\/a>, is developing a membrane with the potential to revolutionize this process by maximizing its efficiency.<\/p>\n

In order for dialysis to eventually become something that patients may undergo from the comfort of their own home, Moghaddam identified two things that needed to change: the configuration of the membrane, and the material from which it was made.<\/em><\/p>\n

\u201cThis membrane is based on simplicity,\u201d Moghaddam said. \u201cIt is based on something that uses forces of physics, rather than brute force.\u00a0 I made it simple through better understanding and utilizing molecular and nanomaterials self-assembly processes.\u201d<\/p>\n

Moghaddam believes that new generation functional life support systems can be developed by advancing the science of materials interactions at both the molecular and nanoscale. In this case, the membrane is composed of two sheets of graphene, one of the thinnest possible existing molecular sieves. The two layers stagger the manmade pores in each sheet, lowering the chances of critical substances passing through.<\/p>\n

\u00a0As barbers joke that the secret to a good haircut is knowing what to leave behind, the same holds true for biomedical filtration.<\/strong><\/p>\n

\"\"
“Graphene is a material that is comparatively quick and inexpensive to mass-produce, making this developing membrane a potentially uniquely positioned solution for the thousands on waiting lists for organ transplants.”<\/figcaption><\/figure>\n

\u201cThe purpose is to be selective,\u201d Moghaddam said. \u201cYou cannot keep losing red blood cells, albumin, or other valuable proteins through defects inherent to typical micro-and nanomanufacturing methods.\u201d<\/p>\n

When it comes to filtration, chemically modified graphene sheets are unparalleled in their adsorptive nature and selective permeability. Daniel Ornt, a clinical nephrologist and the Vice President of Health Sciences at the Rochester Institute of Technology, made sure that the project\u2019s development and testing mimicked a clinical environment as closely as possible. For example, considering how patient experiences might be affected.<\/p>\n

\u201cThe duration of treatment and size of the filter could be dramatically improved, cutting down on time spent at a clinic,\u201d Ornt said.\u00a0 \u201cIt would also lend the dialysis process more speed and selectivity.\u201d<\/p>\n

But not only does the engineering behind the membrane speed up its intended purpose, it takes into account the production value and bigger goal.<\/p>\n

\u201cBoth of us have the philosophy of looking for scalable nanomanufacturing that can be applied to significant problems our country and society faces,\u201d said Thomas Gaborski, Ph.D \u00a0the other PI on the NIH-backed project and associate professor of biomedical engineering at the Rochester Institute for Technology.<\/p>\n

\u201cWe don\u2019t just want to make a new nanomaterial discovery in our lab,\u201d Gaborski said. \u201cWe want to translate this into a technology that can be useful beyond just the limited confines of our own research laboratories.\u201d<\/p>\n

Accordingly, graphene is a material that is comparatively quick and inexpensive to mass-produce, making this developing membrane a potentially uniquely positioned solution for the thousands on waiting lists for organ transplants.\u00a0<\/p>\n

\u201cA liver or kidney transplant is always the best solution, but the supply is woefully inadequate around the world,\u201d Gaborski said. \u201cTechnologies like this are necessary to help patients until that supply becomes available.\u201d<\/p>\n

Gaborski and Moghaddam\u2019s project has received support from NIH and is just one of many recent interdisciplinary collaborations involving the University of Florida. Increasingly, research efforts at the university seek to explore the intersection between medicine and engineering, with innovative and promising results.<\/p>\n

\n

\u201cBy translating ideas from one discipline to another, I believe that we can have a really positive impact,\u201d said David Hahn, chair of the Department of Mechanical and Aerospace Engineering. \u201cIt\u2019s this interdisciplinary approach that we\u2019re hoping to ingrain in our students\u2014the idea that problem solving can be much more effective, and more efficient, if you consider a diversity in approaches.\u201d<\/p>\n<\/blockquote>\n","protected":false},"excerpt":{"rendered":"

Promising results between medicine and engineering show signs of improving patients’ quality of life. <\/p>\n","protected":false},"author":2592,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"single-templates\/single-sidebar-none.php","format":"standard","meta":{"_acf_changed":false,"inline_featured_image":false,"featured_post":"","footnotes":"","_links_to":"","_links_to_target":""},"categories":[23,35,61,57],"tags":[],"class_list":["post-22713","post","type-post","status-publish","format-standard","hentry","category-mae","category-featured","category-research-innovation","category-stories"],"acf":[],"yoast_head":"\nGraphene Membrane Seeks to Drastically Reduce Dialysis Time - News from Herbert Wertheim College of Engineering<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.eng.ufl.edu\/news\/mae\/graphene-membrane-seeks-drastically-reduce-dialysis-time\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Graphene Membrane Seeks to Drastically Reduce Dialysis Time - 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