{"id":43033,"date":"2026-05-15T09:47:00","date_gmt":"2026-05-15T13:47:00","guid":{"rendered":"https:\/\/www.eng.ufl.edu\/news\/?p=43033"},"modified":"2026-05-15T09:47:03","modified_gmt":"2026-05-15T13:47:03","slug":"uf-breakthrough-could-reshape-rna-editing-with-worlds-first-dna-guided-crispr","status":"publish","type":"post","link":"https:\/\/www.eng.ufl.edu\/news\/che\/uf-breakthrough-could-reshape-rna-editing-with-worlds-first-dna-guided-crispr\/","title":{"rendered":"UF breakthrough could reshape RNA editing with world&#8217;s first DNA-guided CRISPR"},"content":{"rendered":"\n<ul class=\"wp-block-list has-light-gray-background-color has-background\">\n<li>The work establishes the world\u2019s first system that uses DNA, rather than RNA, to guide CRISPR enzymes to its target.<\/li>\n\n\n\n<li>Instead of using RNA as a guide, the team engineered CRISPR to use DNA, which is naturally more stable and easier to produce.<\/li>\n\n\n\n<li>The team, in collaboration with researchers at UT Austin, also released the structure of their first DNA-guided CRISPR system in a separate <a href=\"https:\/\/www.biorxiv.org\/content\/10.64898\/2026.03.19.712971v1\">preprint<\/a> in March 2026.<\/li>\n<\/ul>\n\n\n\n<p>A team of engineers at the University of Florida &nbsp;has developed a new form of CRISPR technology that could make diagnostics and treatments safer, more precise and more affordable, while opening the door to entirely new ways of controlling disease.<\/p>\n\n\n\n<p>First reported in a <a href=\"https:\/\/www.medrxiv.org\/content\/10.1101\/2024.11.21.24317744v1\">2024 preprint<\/a> and now formally published this week in <a href=\"https:\/\/www.nature.com\/articles\/s41587-026-03129-w\">Nature Biotechnology<\/a>, the work establishes the world\u2019s first system that uses DNA, rather than RNA, to guide CRISPR enzymes to its target, overturning the long-standing paradigm.<\/p>\n\n\n\n<p><a href=\"https:\/\/news.ufl.edu\/2026\/05\/dna-guided-crispr\/\">Read full story on news.ufl.edu<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>A team of engineers at the University of Florida  has developed a new form of CRISPR technology that could make diagnostics and treatments safer, more precise and more affordable, while opening the door to entirely new ways of controlling disease.<\/p>\n","protected":false},"author":9,"featured_media":43035,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"single-templates\/single-sidebar-none.php","format":"standard","meta":{"_acf_changed":false,"inline_featured_image":false,"featured_post":"off","footnotes":"","_links_to":"","_links_to_target":""},"categories":[11,57,61],"tags":[303],"class_list":["post-43033","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-che","category-stories","category-research-innovation","tag-piyush-jain"],"acf":[],"_links":{"self":[{"href":"https:\/\/www.eng.ufl.edu\/news\/wp-json\/wp\/v2\/posts\/43033","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.eng.ufl.edu\/news\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.eng.ufl.edu\/news\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.eng.ufl.edu\/news\/wp-json\/wp\/v2\/users\/9"}],"replies":[{"embeddable":true,"href":"https:\/\/www.eng.ufl.edu\/news\/wp-json\/wp\/v2\/comments?post=43033"}],"version-history":[{"count":3,"href":"https:\/\/www.eng.ufl.edu\/news\/wp-json\/wp\/v2\/posts\/43033\/revisions"}],"predecessor-version":[{"id":43041,"href":"https:\/\/www.eng.ufl.edu\/news\/wp-json\/wp\/v2\/posts\/43033\/revisions\/43041"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.eng.ufl.edu\/news\/wp-json\/wp\/v2\/media\/43035"}],"wp:attachment":[{"href":"https:\/\/www.eng.ufl.edu\/news\/wp-json\/wp\/v2\/media?parent=43033"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.eng.ufl.edu\/news\/wp-json\/wp\/v2\/categories?post=43033"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.eng.ufl.edu\/news\/wp-json\/wp\/v2\/tags?post=43033"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}