Dr. Reier’s laboratory studies the cell biology of neurons and glia in the developing and injured peripheral and central nervous systems.
It is now recognized that the injured spinal cord has considerable potential for varying degrees of spontaneous recovery. Dr. Reier’s studies focus on therapeutic strategies that can enhance such self-repair. Current translational emphasis is on cervical spinal cord injury, respiratory neuroplasticity, pharmacological modulation of inhibitory molecular influences on axonal growth, and cellular replacement therapies. These studies are pre-clinical by design, and the overall goal is to obtain proof of concept along with safety and efficacy data required for future clinical trials
- Kwon BK, Okon EB, Tsai E, Beattie MS, Bresnahan JC, Magnuson DK, Reier PJ, McTigue DM, Popovich PG, Blight AR, Oudega M, Guest JD, Weaver LC, Fehlings MG, Tetzlaff W. A Grading System To Evaluate Objectively the Strength of Pre-Clinical Data of Acute Neuroprotective Therapies for Clinical Translation in Spinal Cord Injury. J Neurotrauma 2010. 1-19.
- Lee KZ, Sandhu MS, Dougherty BJ, Reier PJ, Fuller DD. Influence of vagal afferents on supraspinal and spinal respiratory activity following cervical spinal cord injury in rats. J Appl Physiol 2010; 109(2):377-387.
- Qiu K, Lane MA, Lee KZ, Reier PJ, Fuller DD. The phrenic motor nucleus in the adult mouse. Exp Neurol 2010; 226(1):254-258.
- White TE, Lane MA, Sandhu MS, O’Steen BE, Fuller DD, Reier PJ. Neuronal progenitor transplantation and respiratory outcomes following upper cervical spinal cord injury in adult rats. Exp Neurol 2010; 225(1):231-236.