Dr. Ormerod’s research focuses on understanding how to use transplantable or endogenous neural stem cells to repair neural circuits in the diseased or injured brain and how changes in levels of hippocampal neurogenesis across lifespan impact cognition. Projects seek to 1) identify pro-geronic factors that impact hippocampal neurogenesis and memory and develop detection assays and strategies to modulate them, 2) identify inflammatory and neuroinflammatory factors that regulate neural stem cell behavior and cognition and develop strategies to modulate them, and 3) identify the functional impact of neuronal addition to diseased or damaged neural circuits. Multidisciplinary projects employ rodents or culture systems that integrate numerous techniques that include behavioral testing, protein quantification using multiplex technology, MEA-monitoring of neuronal activity, and the quantification of cultured and endogenous cell behavior with advanced immunohistochemical and histological techniques, among others.
Honors and Awards:
- Ruth K. Broad Biomedical Research Foundation Extramural Investigator, 2008-2010
- Fellow, Michael J. Fox Foundation Postdoctoral, 2003-2006
- Fellow, Natural Sciences and Engineering Research Council of Canada Predoctoral, 2004-2006