The focus of my research continues to be on determining the neurobiology of age-related memory loss. My lab addresses this question using multiple levels of analysis that include molecular imaging techniques, high-channel count in vivo neurophysiology, and behavioral assessment. Particularly, we are taking the novel approach of trying to understand how aging impacts communication across brain areas that are critical for adaptive behaviors. Age-associated cognitive impairments do not result from alterations to brain structures in isolation. To fully understand cognitive aging, it is therefore imperative to examine how brain areas interact. A powerful tool for pin-pointing disruptions in the complex neural systems that produce cognitive dysfunction during normal aging is the careful analysis of behavior.