BME Seminar Series: Tuberculosis and the Macrophage Populations of the Lung


3:00 pm-4:00 pm
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David G. Russell, Ph.D.
William Kaplan Professor of Infection Biology, Department of Microbiology and Immunology, Cornell University

Mycobacterium tuberculosis remains a major impact on human health globally. Our ability to manage this disease is compromised by the absence of a vaccine and the protracted nature of chemotherapy. This talk will discuss how the interplay between the bacterium and its host cells in vivo impact disease progression, vaccine development and drug susceptibility. We use a combination of fluorescent Mtb fitness reporter strains, genetic manipulation of host and microbe, and multi-modal RNA-seq analysis to probe this complex biology and to develop novel

David G. Russell, Ph.D., is the William Kaplan Professor of Infection Biology in the Department of
Microbiology and Immunology, Cornell University. He received his BSc. from St. Andrews University in Scotland, and his Ph.D. from Imperial College, London. He has held positions at the Max-Planck-Institüt in Tübingen, NYU Medical School, Washington University School of Medicine and Cornell University. He has spent his entire career looking at host/pathogen interplay and has authored over 230 publications on the subject, including papers in Science and Nature. He has active collaborations with UCT, Cape Town, and AHRI, Durban, South Africa and with the MLW Clinical Research Program, Blantyre, Malawi. He was made an Honorary Professor of Immunology at the Malawi College of Medicine in 2015. His work is supported by grants from the National Institutes of Health, USA, and the Bill and Melinda Gates Foundation.


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Dr. Christine Schmidt