BME Postdocs Seminar: Chansoo Choi & Bangho Shin

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Dr. Chansoo Choi : “Enabling Advanced Skeletal Dosimetry in Adults and Children Through Micro-CT–Based Detailed Skeletal Models”
Dr. Bangho Shin: “Micro-Yucatan Minipig Dosimetry Models for Preclinical Radiopharmaceutical Dosimetry”
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Chansoo Choi , PhD
Postdoctoral Associate, Bolch Lab
Biomedical Engineering, University of Florida

“Enabling Advanced Skeletal Dosimetry in Adults and Children Through Micro-CT–Based Detailed Skeletal Models”

Abstract: The skeleton plays a critical role in radiation dosimetry, as it contains red bone marrow and the endosteal region, whose irradiation can lead to radiation-induced leukemia and bone cancer. For this reason, several research groups have developed skeletal models for dosimetric purposes using imaging techniques such as micro-CT. However, due to structural and technical limitations, these models still exhibit various dosimetric shortcomings. Furthermore, despite their importance, skeletal models for children, beyond those developed for adults, have remained unavailable. Recently, we have successfully overcome these limitations by developing high-fidelity skeletal models based on micro-CT images and advanced mesh deformation techniques for both adults and children, enabling advanced skeletal dosimetry. In addition, through this work, we identified the potential to extend this framework toward the generation of patient-specific skeletal models. This seminar will cover the background and development of these skeletal models, their dosimetric impact, and implications for future research and applications.

Bio: Dr. Chansoo Choi is an expert in radiation dosimetry with a focus on radiation protection and safety. He is currently a Postdoctoral Associate in the J. Crayton Pruitt Family Department of Biomedical Engineering at the University of Florida, where he works in the laboratory of Prof. Wesley E. Bolch. Prior to joining the University of Florida in August 2022, he received his B.S. and Ph.D. degrees in Nuclear Engineering from Hanyang University in Korea. His research focuses on the development of high-fidelity computational phantoms derived from medical imaging and their application to advanced radiation dosimetry using Monte Carlo radiation transport techniques. The pediatric computational phantoms developed by Dr. Choi have been adopted by the International Commission on Radiological Protection (ICRP) as international reference models for pediatric radiation dosimetry and have been in official use since 2024.
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Bangho Shin, PhD
Postdoctoral Associate, Bolch Lab
Biomedical Engineering, University of Florida

“Micro-Yucatan Minipig Dosimetry Models for Preclinical Radiopharmaceutical Dosimetry”

Abstract: Radiopharmaceutical therapy (RPT) delivers radionuclides to target tissues via vectors such as small molecules, peptides, and antibodies, enabling targeted treatment of tumors. In the preclinical phase of radiopharmaceutical development, animal models play a critical role in estimating absorbed doses distributed throughout the body. Minipigs are valuable mid-sized experimental models due to their anatomical and physiological similarities to humans. Despite their importance, computational dosimetry models for minipigs are currently unavailable, limiting accurate internal dose estimation in preclinical studies. To address this gap, micro-Yucatan minipig computational models are being developed based on computed tomography (CT) and magnetic resonance (MR) images of 6-month-old male and female minipigs. In this talk, I will introduce the anatomical construction of these models and discuss their dosimetric features, with a focus on applications in preclinical radiopharmaceutical dosimetry.

Bio: Dr. Bangho Shin is a postdoctoral associate in the Advanced Laboratory for Radiation Dosimetry Studies (ALRADS), led by Prof. Wesley E. Bolch, in the Department of Biomedical Engineering (BME) at the University of Florida (UF). He received his B.S. and Ph.D. degrees in Nuclear Engineering from Hanyang University, Seoul, Republic of Korea. Dr. Shin specializes in computational phantoms and their applications in radiation dosimetry. He is currently a member of Task Group 103 (Mesh-type Reference Computational Phantoms, MRCPs) and Task Group 130 (Doses from Diagnostic Radiopharmaceuticals During Pregnancy and Breastfeeding) of the International Commission on Radiological Protection (ICRP). He is the primary developer of the ICRP pregnant-female MRCPs, which will serve as the internal gold standard human model for dose assessment to pregnant women and fetuses.