Using Electrophysiology to Improve DBS Therapy
Coralie de Hemptinne, PhD
Assistant Professor of Neurology
Tuesday: September 12, 2023
Deep brain stimulation (DBS) can be an effective treatment to address motor symptoms and fluctuations in individuals with Parkinson’s disease (PD). However, current therapy delivers electrical stimulation to the brain irrespective of symptoms, resulting in suboptimal stimulation. Selecting the stimulation parameters is a manual, trial-and-error process that is laborious and time consuming. Our projects aim to improve the efficiency and efficacy of DBS by using electrophysiology to automatically select stimulation parameters and develop adaptive DBS algorithms. We record brain activity both acutely during DBS implantation surgery and chronically in the patient’s home environment, correlate it with symptom severity, and determine the effect of stimulation.
Dr. Coralie de Hemptinne is an assistant professor in the Normal Fixel Institute for Neurological Diseases. She earned her B.S degree in Biology from the Universite Libre de Bruxelles and her MS and PhD in Neuroscience from the Universite Catholique de Louvain in Belgium. She worked in Dr. Philip Starr’s laboratory at UCSF as a postdoctoral fellow and then as a research associate from 2010-2020. The current aim of her research is to understand the pathophysiology underlying motor and non-motor symptoms in Parkinson’s disease patients, using invasive chronic, multisite recordings. Her ultimate goal is to develop new neuromodulation strategies for Parkinson’s disease and other movement disorders.